P-21 activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils Pak regulates phagocyte NADPH oxidase
نویسندگان
چکیده
P-21 activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils Pak regulates phagocyte NADPH oxidase Kendra D. Martyn, Moon-Ju Kim, Mark T. Quinn, Mary C. Dinauer and Ulla G. Knaus These authors contributed equally to this work Dr. Martyn and Dr. Kim performed research Dr. Quinn and Dr. Dinauer contributions are essential reagents and manuscript revision Dr. Knaus designed and performed research, analyzed data, and wrote the manuscript
منابع مشابه
A p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidase.
Chemoattractant-stimulated phagocytes increase their glucose uptake and divert energy production from glycolysis to the pentose phosphate pathway to generate NADPH. NADPH is a required cofactor for the NADPH oxidase to produce reactive oxygen metabolites, an important microbicidal tool in host defense. p21-Activated kinases (Paks) are regulated by the GTPases Rac and Cdc42 and control actin dyn...
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